Lady Mary Montagu
In 2020, it is not surprising that there are many women playing a prominent part in developing vaccines to protect us against the current scourge—Covid 19. I know nothing about this field, but a casual search threw up many names—Prof Sarah Gilbert, Dr. Kizzmekia Corbett, Dr. Nita Patel. And Dr. Patel had a good explanation—she says that lab work in science is mostly done by women, so it is not surprising that women are prominent in the race to find the vaccine.
But it was not always so. Even though women have played a critical role in the development of many vaccines, they have not always got their due.
Polio was a dreaded disease in the early 20th century. It left death in its wake, but even more, it paralysed. Till date, there is no cure for polio, and the only defence is vaccination. Jonas Salk rightly deserves the credit for the polio vaccine, but there were two women, without whose work things would not have happened as they happened, when they happened. One was Dr. Isabel Morgan of Johns Hopkins University, whose work was a turning point in understanding host immunity to polio and on use of killed-virus (vs. live-virus) as the basis of vaccines for this disease. The other was Dr. Dorothy Horstmann of Yale and her team, whose work is said to have paved the way for oral polio vaccines.
Other women to whom we owe a safer world are: Dr. Anna Wessels Williams, who developed a diphtheria vaccine; Drs. Pearl Kendric and Grace Eldering who developed a vaccine for whooping cough; Dr. Margeret Pittman, whose work led to the vaccine against meningitis and pneumonia; Dr. Anne Szarewski, whose breakthroughs helped to develop vaccines against cervical cancers; and Dr. Ruth Bishop who led the team which developed a vaccine against rotavirus which is a major cause for diarrhoea in children.
But the best for the last! The most amazing story is of the woman who introduced the concept of immunization to the Western world, Lady Mary Montagu. Born in 1689, she was a path-breaker in many ways. But her contribution to vaccination is the one we are going to focus on here. She was a brilliant and beautiful woman, whose beauty was marred by an attack of smallpox in 1715. Earlier she had lost her brother to it. So it was no wonder that the deadly disease was something she worried about where her children were concerned. Lady Mary’s husband Lord Edward Montagu was posted to Constantinople as Ambassador in 1716. There she interacted closely with Turkish women and got to know their customs. One of these was the practice of variolation, wherein women would take the pus from the smallpox blister of someone who had a mild case of the disease, and introduce it into the scratched skin of uninfected children. Lady Mary observed that children thus infected never did contract the disease seriously.
She developed such a strong belief in this that she got the Embassy surgeon to inoculate her five year old son.
When she got back to England, she promoted this procedure with all her passion, but the medical establishment blocked and resisted it. The reasons are probably two-fold—it was seen as an Oriental folk treatment, not a Western, scientific one. And it was being promoted by a woman!
In 1721, a smallpox epidemic struck England, and Lady March had her daughter also inoculated. She persuaded the Princes of Wales on the efficacy of this, and the Princess had her two daughters inoculated. And though it took a long, long time for Jenner to come along and develop a safer technique of vaccination, using cowpox rather than smallpox virus, the concept started taking root, and the foundation for vaccination had been laid!
With thanks to all the back room girls (and boys) helping find vaccines and cures, as well as all front line workers.
–Meena
But that is not the subject of the blog today. April 25th is marked as World Penguin Day, and that is the occasion of the blog. This day coincides with the annual northern migration of Adelie penguins.
The connection is a tree that is reputed to be the most instagrammed tree in New Zealand, almost a symbol of NZ tourism. On a recent trip there, we were urged to set aside time to see the tree, specifically around sunset. So we worked around our program to ensure we got to the spot—a stretch of a beach—well ahead. We drove past a few times, keenly looking at the beach. We could see some people, but nothing special in the way of trees. We asked natives and tourists alike, and they all pointed us to the same area which our GPS had shown us, and which we had passed, looking in vain for a landmark. We decided to make our way down to the beach anyway. Lo and behold, there were many, many people there, jostling for some spot (we could not figure out what the spot was for), all setting up professional looking camera equipment. It came to a pass when we had to ask a friendly-looking lady what everyone was waiting to photograph, where the famous tree was, and what it was about. She kindly pointed to this spindly willow tree, standing a few feet into the waters of the beautiful Wanaka Lake, against a beautiful background of majestic mountains. But the tree itself? In my mind, this will forever define and exemplify ‘under-whelming’. ‘Why is the tree famous’, we asked many around us in bewilderment. While there was some story of how it was part of a fence and had survived in the water for several years, the general consensus was that it was famous because it was famous! So famous , it even has its own insta handle #ThatWanakaTree.
Pencil sketch, V. Raghunathan, using 3B and 4B pencils. 1980.
AESTIVATION, lesser known cousin of hibernation, is ‘summer sleep’– a survival strategy used by many vertebrates and invertebrates to endure arid environmental conditions. Key features of aestivation, like hibernation (winter dormancy) include significant metabolic rate suppression, conservation of energy , altered nitrogen metabolism, and mechanisms to preserve and stabilize organs and cells over many weeks or months of dormancy. Even more than in hibernation, strategies to retain body water are important in aestivation, as dryness or aridity is the key trigger for the summer sleep.
But for a South Indian like me, the most important person-colour association has of course to be ‘MS Blue’, said to be a favourite of legendary singer M.S. Subbalakshmi. This colour became synonymous with her after she started wearing Kanchipuram silk saris of this shade at her concerts. These were specially made for her by Muthu Chettiar, a weaver from Madurai. The savvy businessman that he was, he carefully regulated supplies to ensure enduring demand from Madras high society ladies! It has been clarified that MS Blue is not peacock blue but ‘mid-sea blue’.
cutta, but Bangalore was also Sir Raman’s ‘karma bhoomi’, in that he worked at the Indian Institute of Science from 1933 till his retirement in 1948, after which he founded the Raman Research Institute in the city, and continued working there till his death in 1970.
n I was growing up in Delhi, house sparrows were very much a part of our lives. They were everywhere, and by the dozens. In fact, most children of those times got their first nature lessons by watching sparrows—the sex differentiation, how they built their nests, the eggs hatching and the parents feeding the young, their mud-bathing etc.
Millennial Matriarchs 